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Uch-L1 C-terminal hydrolase activity can be measured in vitro by an enzyme assay using the fluorogenic substrate Ub-AMC, and its activity can be effectively inhibited by the specific inhibitor LDN-57444 (Wilkinson et al., 1989

A separate strategic bet is Rebyota the first FDA-approved live biotherapeutic product for recurrent Clostridioides difficile infection marking Ferring's entry into the microbiome therapy space and diversifying its peptide-centric portfolio

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In contrast, the small-molecule compound Necrostatin-1 has shown potential in inhibiting necroptosis and protecting ovarian reserve

R., Elhelaly, A